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Curr Opin Struct Biol. 2001 Feb;11(1):120-4.

The endoplasmic reticulum: integration of protein folding, quality control, signaling and degradation.

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1
Anatomy and Cell Biology, McGill University, Montreal, Quebec, H3A 2B2, Canada.

Abstract

The endoplasmic reticulum is the entry point into the secretory pathway. To acquire a correct conformation, secretory proteins encounter the endoplasmic reticulum molecular machines of folding, quality control, signaling and disposal, which function as an integrated mechanism. The creation of such a molecular network, spatially regulated, suggests how the endoplasmic reticulum promotes the release of correctly folded secretory proteins.

PMID:
11179901
[Indexed for MEDLINE]
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