Format

Send to

Choose Destination
Curr Opin Neurobiol. 2001 Feb;11(1):111-7.

The role of Notch and Rho GTPase signaling in the control of dendritic development.

Author information

1
Department of Neuroscience, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore MD 21205, USA. lredmond@jhmi.edu

Abstract

Dendritic patterning exerts a profound influence on neuronal connectivity. Recent studies indicate that mammalian Notch receptors are expressed by postmitotic neurons and that Notch signaling has a considerable influence on dendritic growth and branching. Investigations into the intracellular effectors of dendritic development have revealed that dendritic growth and branching are differentially affected by activation of the Rho-family GTPases, RhoA, Rac1, and Cdc42. These observations suggest that the differential activation of Notch receptors and Rho-family GTPases by extracellular signals may be important in the generation of morphological diversity in the developing nervous system.

PMID:
11179880
DOI:
10.1016/s0959-4388(00)00181-1
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center