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Curr Opin Neurobiol. 2001 Feb;11(1):89-94.

Repulsive factors and axon regeneration in the CNS.

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Department of Neurology and Section of Neurobiology, Yale University School of Medicine, PO Box 208018, New Haven, Connecticut 06520, USA.


During the past year, a major advance in the study of axon regeneration was the molecular cloning of Nogo. The expression of Nogo protein by CNS myelin may be a major factor in the failure of CNS axon regeneration. The effect of disrupting Nogo-dependent axon inhibition can now be studied conclusively. In related work, immunization with a Nogo-containing CNS myelin preparation was shown to promote regeneration and dramatic functional recovery after spinal cord trauma.

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