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Trends Biotechnol. 2001 Mar;19(3):114-20.

Telomerase inhibitors.

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1
Depts of Internal Medicine and Cell Biology, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390-9039, USA.

Abstract

There has been a vast increase in telomerase research over the past several years, with many different pre-clinical approaches being tested for inhibiting the activity of this enzyme as a novel therapeutic modality to treat malignancy. In this review, we will provide some basic background information about telomeres and telomerase and then discuss the pros, cons and challenges of the approaches that are currently under investigation, and what we might expect in the future of this emerging field.

PMID:
11179805
[Indexed for MEDLINE]
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