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Genome Biol. 2001;2(1):REVIEWS3002. Epub 2001 Jan 12.

Replicative DNA polymerases.

Author information

1
Wohl Virion Centre, Department of Immunology and Molecular Pathology, University College London, Cleveland Street, London, W1T 4JF, UK. m.alba@ucl.ac.uk

Abstract

Replicative DNA polymerases are essential for the replication of the genomes of all living organisms. On the basis of sequence similarities they can be classified into three types. Type A polymerases are homologous to bacterial polymerases I, Type B comprises archaebacterial DNA polymerases and eukaryotic DNA polymerase alpha, and the bacterial polymerase III class make up type C. Structures have been solved for several type A and B polymerases, which share a similar architecture. The structure of type C is not yet known. The catalytic mechanism of all three types involves two metal-ion-binding acidic residues in the active site. Replicative polymerases are constitutively expressed, but their activity is regulated through the cell cycle and in response to different growth conditions.

PMID:
11178285
PMCID:
PMC150442
DOI:
10.1186/gb-2001-2-1-reviews3002
[Indexed for MEDLINE]
Free PMC Article

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