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Genome Biol. 2000;1(4):REVIEWS0004. Epub 2000 Oct 13.

An overview of the potassium channel family.

Author information

1
HHMI and Department of Biochemistry, Brandeis University, Waltham, MA 02454, USA. cmiller@brandeis.edu

Abstract

Potassium channels, tetrameric integral membrane proteins that form aqueous pores through which K+ can flow, are found in virtually all organisms; the genomes of humans, Drosophila, and Caenorhabditis elegans contain 30-100 K+ channel genes each. The structure of a bacterial K+ channel, sequence comparisons with other channels and electrophysiological measurements have enabled conclusions about the mechanism of gating and ion flow to be drawn for many other channels.

PMID:
11178249
PMCID:
PMC138870
DOI:
10.1186/gb-2000-1-4-reviews0004
[Indexed for MEDLINE]
Free PMC Article

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