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Bull Exp Biol Med. 2000 Oct;130(10):969-72.

Neuroprotective properties of nootropic dipeptide GVS-111 in in vitro oxygen-glucose deprivation, glutamate toxicity and oxidative stress.

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Brain Research Institute, Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow. nadja@


Argon anoxia and glucose deprivation were used for modeling of ischemic damage in the cultures of cerebellar granule cells. Protective effect of peptide piracetam analogue GVS-111 was demonstrated. GVS-111 prevented neurodegeneration induced by glutamate and oxidative stress. In contrast to GVS-111, piracetam did not attenuate neurocytotoxic effect of glutamate.

[Indexed for MEDLINE]

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