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JAMA. 2001 Feb 7;285(5):588-93.

Toward mechanism-based cancer care.

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Division of Neoplastic Disease Mechanisms, Dana-Farber Cancer Institute, 44 Binney St, Boston, MA 02115, USA.


In the past 25 years, research has elucidated molecular mechanisms directing key aspects of tumor cell behavior. Detailed understanding of these mechanisms has already changed methods for diagnosis, prognosis, and treatment. With continuing advances in cancer science and the emergence of new technologies for applying basic science to clinical practice, new methods based on molecular mechanisms will dominate cancer care and prevention.

[Indexed for MEDLINE]

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