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J Urol. 2001 Feb;165(2):371-3.

A brief history of testosterone.

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  • 1Department of Surgery, University of Michigan, Ann Arbor, Michigan, USA.

Abstract

PURPOSE:

We explore the history of testosterone in the context of medical and scientific developments.

MATERIALS AND METHODS:

A review of the scientific and historical literature was conducted.

RESULTS:

The origins and effects of testosterone have been recognized throughout the history of humankind. Hunter performed testicular transplantation experiments in 1767 while studying tissue transplantation techniques, and almost a century later Berthold linked the physiological and behavioral changes of castration to a substance secreted by the testes. Brown-Séquard gave birth to the field of organotherapy in 1889 when he announced that his auto-injection of testicular extracts resulted in rejuvenated physical and mental abilities. Steinach and Niehans expanded upon Brown-Séquard's work with rejuvenation treatments involving vasoligation, tissue grafts and cellular injections. In 1935 David et al isolated the critical ingredient in organotherapeutic treatments, testosterone.

CONCLUSIONS:

The effects of the powerful hormone testosterone continue to inspire research and controversy 65 years later.

[PubMed - indexed for MEDLINE]
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