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Nat Med. 2001 Feb;7(2):161-6.

Genetic models for CNS inflammation.

Author information

1
Neuroimmunology Unit, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada. trevor@med.mcgill.ca

Abstract

The use of transgenic technology to over-express or prevent expression of genes encoding molecules related to inflammation has allowed direct examination of their role in experimental disease. This article reviews transgenic and knockout models of CNS demyelinating disease, focusing primarily on the autoimmune disease multiple sclerosis, as well as conditions in which an inflammatory response makes a secondary contribution to tissue injury or repair, such as neurodegeneration, ischemia and trauma.

PMID:
11175845
DOI:
10.1038/84603
[Indexed for MEDLINE]

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