Format

Send to

Choose Destination
Nat Genet. 2001 Feb;27(2):167-71.

Regulatory element detection using correlation with expression.

Author information

1
Center for Studies in Physics and Biology, The Rockefeller University, New York, New York, USA. bussemaker@bio.uva.nl

Abstract

We present here a new computational method for discovering cis-regulatory elements that circumvents the need to cluster genes based on their expression profiles. Based on a model in which upstream motifs contribute additively to the log-expression level of a gene, this method requires a single genome-wide set of expression ratios and the upstream sequence for each gene, and outputs statistically significant motifs. Analysis of publicly available expression data for Saccharomyces cerevisiae reveals several new putative regulatory elements, some of which plausibly control the early, transient induction of genes during sporulation. Known motifs generally have high statistical significance.

PMID:
11175784
DOI:
10.1038/84792
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Nature Publishing Group
Loading ...
Support Center