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Nat Genet. 2001 Feb;27(2):153-4.

Epigenetic change in IGF2R is associated with fetal overgrowth after sheep embryo culture.

Author information

1
Roslin Institute (Edinburgh), Roslin, Midlothian, Scotland, UK. Lorraine.Young@bbsrc.ac.uk

Abstract

Manipulation or non-physiological embryo culture environments can lead to defective fetal programming in livestock. Our demonstration of reduced fetal methylation and expression of ovine IGF2R suggests pre-implantation embryo procedures may be vulnerable to epigenetic alterations in imprinted genes. This highlights the potential benefits of epigenetic diagnostic screening in developing embryo procedures.

PMID:
11175780
DOI:
10.1038/84769
[Indexed for MEDLINE]

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