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J Pediatr. 2001 Feb;138(2):244-9.

First-phase insulin release during the intravenous glucose tolerance test as a risk factor for type 1 diabetes.

Author information

1
Barbara Davis Center, University of Colorado Health Sciences Center, Denver, USA.

Abstract

OBJECTIVE:

To determine the relationship between first-phase (1 minute + 3 minutes) insulin production during the intravenous glucose tolerance test (IV-GTT) and risk factors for developing type 1 diabetes.

STUDY DESIGN:

Relatives of persons with type 1 diabetes (n = 59,600) were screened for islet cell antibodies (ICAs). Subjects who had positive screening results underwent IV-GTT (> or =2 times), repeat ICA screening, insulin autoantibody (IAA) screening twice, and an oral glucose tolerance test.

RESULTS:

Of the 59,600 subjects in the study, 2199 (3.69%) had positive findings on initial ICA test. IV-GTTs were performed in 1622 subjects, with children <8 years having the lowest first-phase insulin release (FPIR) and subjects 8 to 20 years of age having the highest FPIR. The FPIR was lower for subjects with a confirmed positive ICA test result or a positive IAA test result, subjects with higher titers of ICA or IAA, and subjects who had an abnormal (impaired or diabetic) oral glucose tolerance test result.

CONCLUSION:

FPIR in the IV-GTT correlates strongly with risk factors for development of type 1 diabetes.

PMID:
11174623
DOI:
10.1067/mpd.2001.111274
[Indexed for MEDLINE]

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