Abstract
In a randomized, controlled study of 80 patients with advanced colorectal carcinoma, the combination of 5-fluorouracil (5-FU), methyl-1, 3-cis(2-chlorethyl)-1-nitrosourea, and vincristine produced an overall degree to toxicity comparable to that of 5-FU used alone. At 10 weeks, a positive objective response rate of 43.5% was observed with the three-drug combination compared to 19.5% with 5-FU alone (P less than 0.5).
Publication types
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Clinical Trial
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Comparative Study
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Randomized Controlled Trial
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Antineoplastic Agents / administration & dosage
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Antineoplastic Agents / adverse effects
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Antineoplastic Agents / therapeutic use*
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Colonic Neoplasms / drug therapy*
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Cyclohexanes / adverse effects
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Cyclohexanes / analogs & derivatives
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Cyclohexanes / therapeutic use
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Evaluation Studies as Topic
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Female
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Fluorouracil / administration & dosage
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Fluorouracil / adverse effects
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Fluorouracil / therapeutic use*
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Humans
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Male
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Middle Aged
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Nitrosourea Compounds / administration & dosage
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Nitrosourea Compounds / adverse effects
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Nitrosourea Compounds / therapeutic use*
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Rectal Neoplasms / drug therapy*
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Vincristine / administration & dosage
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Vincristine / adverse effects
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Vincristine / therapeutic use*
Substances
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Antineoplastic Agents
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Cyclohexanes
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Nitrosourea Compounds
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Vincristine
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Fluorouracil