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Neuroepidemiology. 2001 Feb;20(1):2-6.

Environmental risk factors for amyotrophic lateral sclerosis.

Author information

1
Department of Neurology, Loma Linda University School of Medicine, Loma Linda, Calif 92354, USA.

Abstract

In order to evaluate reported associations of environmental risk factors with amyotrophic lateral sclerosis (ALS), consideration is given first to robust clinical and epidemiologic observations. These are observations which have persisted in time, have been replicated consistently and likely reflect the reality of the disease. Sporadic, familial and Western Pacific ALS are considered. In contrast, other associations appear to have emerged due to chance, sometimes compounded by faulty study design, and have dissipated once greater attention was given to methodological rigor. Current data suggest that there are no robust environmental risk factors for sporadic ALS.

PMID:
11174039
DOI:
10.1159/000054751
[Indexed for MEDLINE]

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