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Cytogenet Cell Genet. 2000;91(1-4):67-71.

TSPY variants in six loci on the human Y chromosome.

Author information

1
Institut für Humangenetik, Medizinische Hochschule, Hannover, Germany.

Abstract

We have studied the structure, organization, and evolution of the human TSPY gene family by mapping three sequence variants identified through RT-PCR analysis onto genomic clones derived from two different YAC contigs. TSPY gene family members occur in at least six locations on the human Y chromosome, and each cluster contains a unique combination of variants. Our data further suggest that an 18-bp tandem duplication found in TSPY exon 1 originated from an unequal sister chromatid exchange between two tandemly arranged TSPY clusters.

PMID:
11173833
DOI:
10.1159/000056821
[Indexed for MEDLINE]

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