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Fertil Steril. 2001 Feb;75(2):342-7.

Intracytoplasmic sperm injection increased fertilization and good-quality embryo formation in patients with non-male factor indications for in vitro fertilization: a prospective randomized study.

Author information

1
Toronto Fertility Sterility Institute, 66 Avenue Road, Toronto, Ontario, Canada, M5R 3N8. tfsi@aaa-tfsi.cim

Abstract

OBJECTIVE:

To compare the fertilization rate and formation of good-quality embryos with conventional IVF and ICSI in patients with non-male factor infertility.

DESIGN:

Prospective controlled study.

SETTING:

Infertility clinic.

PATIENT(S):

Thirty-five patients with non-male factor infertility.

INTERVENTION(S):

Retrieved sibling oocytes were randomly assigned to conventional IVF or ICSI. Of sibling oocytes assigned to ICSI, only metaphase II oocytes were injected with sperm.

MAIN OUTCOME MEASURE(S):

Fertilization rate and formation of good-quality embryos per retrieved oocyte.

RESULT(S):

Per retrieved oocyte, ICSI resulted in better fertilization rate compared with conventional IVF (71.3% [134 of 188] vs. 57.2% [107 of 187]). Per retrieved oocyte, ICSI also resulted in better formation of good-quality embryos at 48 hours after retrieval compared with conventional IVF (64.4% [121 of 188] vs. 47.1% [88 of 187]).

CONCLUSION(S):

In IVF patients with non-male factor infertility, subjecting some sibling oocytes to ICSI increased the fertilization rate and formation of good-quality embryos per retrieved oocyte. It also avoided the problem of total fertilization failure in almost all cases.

PMID:
11172837
[Indexed for MEDLINE]

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