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Fertil Steril. 2001 Feb;75(2):337-41.

Progesterone supplementation during early gestation after in vitro fertilization has no effect on the delivery rate.

Author information

1
The Fertility Clinic 4071, The Juliane Marie Center, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, DK-2100 Copenhagen, Denmark.

Abstract

OBJECTIVE:

To compare the delivery rate with IVF or ICSI in women who did and did not receive progesterone supplementation in the first 3 weeks after a positive hCG test result.

DESIGN:

Retrospective study.

SETTING:

Fertility Clinic, Rigshospitalet University Hospital, Copenhagen, Denmark.

PATIENT(S):

200 pregnant women who did not receive progesterone (intervention group) and 200 pregnant women who received progesterone for 3 weeks after a positive hCG result.

INTERVENTION(S):

In the study group, vaginal progesterone therapy was withdrawn on the day of positive hCG result. In the control group, treatment with progesterone, 600 mg/d, was continued for 3 weeks after a positive hCG result. Both groups received 600 mg of progesterone starting on the day of embryo replacement until testing positive for pregnancy 14 days after embryo transfer.

MAIN OUTCOME MEASURES:

Delivery rate.

RESULT(S):

The number of deliveries was 126 in the study group and 128 in the control group.

CONCLUSION(S):

The delivery rate was the same in pregnant women who received and those who did not receive progesterone for 3 weeks after a positive hCG result. Progesterone supplementation for more than 2 weeks after embryo transfer may therefore yield no benefit in terms of pregnancy.

PMID:
11172836
DOI:
10.1016/s0015-0282(00)01709-x
[Indexed for MEDLINE]

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