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FEBS Lett. 2001 Feb 9;490(1-2):1-6.

NADP-malic enzyme from plants: a ubiquitous enzyme involved in different metabolic pathways.

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Centro de Estudios Fotosintéticos y Bioquímicos, Universidad Nacional de Rosario, CONICET, Suipacha 531, 2000, Rosario, Argentina.


NADP-malic enzyme (NADP-ME) is a widely distributed enzyme that catalyzes the oxidative decarboxylation of L-malate. Photosynthetic NADP-MEs are found in C4 bundle sheath chloroplasts and in the cytosol of CAM plants, while non-photosynthetic NADP-MEs are either plastidic or cytosolic in various plants. We propose a classification of plant NADP-MEs based on their physiological function and localization and we describe recent advances in the characterization of each isoform. Based on the alignment of amino acid sequences of plant NADP-MEs, we identify putative binding sites for the substrates and analyze the phylogenetic origin of each isoform, revealing several features of the molecular evolution of this ubiquitous enzyme.

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