Send to

Choose Destination
Front Biosci. 2001 Feb 1;6:D120-34.

Neurophysiologic mechanisms of attention: a selective review of early information processing in schizophrenics.

Author information

Department of Psychiatry and Neurology,Tulane University Health Sciences Center, 1440 Canal St., New Orleans, LA 70112, USA.


Attention is an integral component of information processing. A pronounced attention deficit exists among people with schizophrenia and their first-degree relatives as compared to persons without this pathology. Schizophrenics demonstrate marked deficiencies on psychophysical tasks that require temporal and / or spatial integration, properties that are associated with the two primary visual pathways composed of magnocellular (M) and parvocellular (P) cells, respectively. The deficit expresses itself as a dysfunctional information processing system that affects higher order processes, for example, perceptual ability and memory. The focus of this review is to integrate results from several divergent areas of research to include those studies that identify the contributions of the M and P pathways associated with information processing and the attention deficit. The diverse approaches reviewed in this chapter converge to provide a neurophysiologic explanation of the attention deficit in schizophrenia.

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Frontiers in Bioscience
Loading ...
Support Center