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J Med Chem. 2001 Feb 15;44(4):627-32.

Synthesis of new cyclitol compounds that influence the activity of phosphatidylinositol 4-kinase isoform, PI4K230.

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Research Group of Antibiotics of the Hungarian Academy of Sciences, University of Debrecen, P.O. Box 70, Debrecen H-4010, Hungary.


The synthesis, chemical derivatization, and investigation of the inhibitory properties of novel cyclitol derivatives on the phosphatidylinositol 4-kinase enzymes PI4K55 and PI4K230 involved in the phosphatidylinositol cycle are reported. Some of the prepared cyclitol derivatives (i.e. 9, 11, 12, and 14) proved to be very powerful and specific irreversible inhibitors of PI4K230 at or below a concentration of 1 mM.

[Indexed for MEDLINE]

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