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Biopolymers. 2000;55(4):288-96.

Peptide methionine sulfoxide reductase: biochemistry and physiological role.

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Hospital for Special Surgery, Weill Medical College of Cornell University New York, NY 10021, USA.


The oxidation of methionine to methionine sulfoxide both in vivo and in vitro can lead to the loss of biological activity in a variety of proteins. This loss of activity can be reversed by an enzyme called methionine sulfoxide reductase. The gene for this enzyme has been cloned and sequenced from a variety of prokaryotic and eukaryotic cells, and the deduced amino acid sequence is very highly conserved. The mechanism of action of the bovine enzyme has been shown to involve a critical cysteine residue located at position 72 of the protein. In addition to its role as a "repair" enzyme, other evidence suggests that the enzyme may be involved in bacterial adherence and regulation of protein activity.

[Indexed for MEDLINE]

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