Format

Send to

Choose Destination
J Appl Microbiol. 2001 Feb;90(2):223-8.

Isolation of human faecal bifidobacteria which reduce signs of Salmonella infection when orogastrically dosed to mice.

Author information

1
CRC for Food Industry Innovation, School of Microbiology and Immunology, University of New South Wales, Sydney, NSW, 2052, Australia. a.henriksson@unsw.edu.au

Abstract

AIMS:

The aim of the study was to isolate human bifidobacteria that inhibit growth of Salmonella typhimurium in vitro, and provide protection against Salmonella infection in mice.

METHODS AND RESULTS:

A total of 92 micro-organisms, which displayed antagonist activity against Salm. typhimurium in vitro, were isolated from human faecal material. Based on their Gram stain status, cultures were pooled and tested for anti-Salmonella activity. The Gram-variable group was the most active. From that group, three bifidobacteria (Laftitrade markB22, B74 and B97) individually showed good pathogen inhibition in vivo.

CONCLUSION:

Oral administration of certain human bifidobacteria provides protection against Salmonella infection in mice.

SIGNIFICANCE AND IMPACT OF THE STUDY:

These results indicate that certain bifidobacteria may be used as a prophylaxis for reduced incidence and severity of Salmonella infections.

PMID:
11168725
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center