Format

Send to

Choose Destination
Trends Endocrinol Metab. 2001 Mar;12(2):48-52.

What is the role of circulating IGF-I?

Author information

1
Clinical Endocrinology Branch, NIDDK, National Institutes of Health, Bethesda, MD 20892-1758, USA. derek@helix.nih.gov

Abstract

Postnatal growth and development are coordinated by genetic and environmental influences and numerous growth factors. The growth hormone-insulin-like growth factor-I (GH-IGF-I) axis plays an essential role in these processes. Although the GH-IGF-I axis is a closely coordinated system, both GH and IGF-I have independent actions, many of which have become apparent more recently following the characterization of clinical syndromes and the development of mouse models. Genetic manipulation of mice has enabled investigators to re-examine many of the established hypotheses regarding the GH-IGF-I axis. Results gleaned from a mouse model created by tissue-specific gene deletion of liver IGF-I has enabled investigators to re-evaluate the original 'somatomedin hypothesis'.

PMID:
11167121
DOI:
10.1016/s1043-2760(00)00349-0
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center