Format

Send to

Choose Destination
Trends Biochem Sci. 2001 Feb;26(2):112-7.

A mitochondrial perspective on cell death.

Author information

1
Dept. of Biomedical Sciences, Viale Giuseppe Colombo 3, I-35121, Padova, Italy. bernardi@civ.bio.unipd.it

Abstract

The role of mitochondria as crucial participants in cell death programs is well established, yet the mechanisms responsible for the release of mitochondrial activators and the role of BCL2 family proteins in this process remain controversial. Here, we point out the limitations of current approaches used to monitor the physiological responses of mitochondria during cell death, the implications arising from modern views of mitochondrial structure, and briefly assess two proposed mechanisms for the release of mitochondrial proteins during apoptosis.

PMID:
11166569
DOI:
10.1016/s0968-0004(00)01745-x
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center