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Trends Biochem Sci. 2001 Feb;26(2):79-83.

RUN domains: a new family of domains involved in Ras-like GTPase signaling.

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Systèmes moléculaires et Biologie structurale, CNRS UMR 7590, Universités Paris 6 & Paris 7, case 115, 4 place Jussieu, 75252 Paris 05, Cedex, France.


RUN domains are present in several proteins that are linked particularly to the functions of GTPases in the Rap and Rab families. They could hence play an important role in multiple Ras-like GTPase signaling pathways.

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