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Trends Microbiol. 2001 Jan;9(1):34-9.

Mechanisms of biofilm resistance to antimicrobial agents.

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1
Dept of Microbiology and Immunology, Dartmouth Medical School, Hanover, NH 03755, USA.

Abstract

Biofilms are communities of microorganisms attached to a surface. It has become clear that biofilm-grown cells express properties distinct from planktonic cells, one of which is an increased resistance to antimicrobial agents. Recent work has indicated that slow growth and/or induction of an rpoS-mediated stress response could contribute to biocide resistance. The physical and/or chemical structure of exopolysaccharides or other aspects of biofilm architecture could also confer resistance by exclusion of biocides from the bacterial community. Finally, biofilm-grown bacteria might develop a biofilm-specific biocide-resistant phenotype. Owing to the heterogeneous nature of the biofilm, it is likely that there are multiple resistance mechanisms at work within a single community. Recent research has begun to shed light on how and why surface-attached microbial communities develop resistance to antimicrobial agents.

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PMID:
11166241
[Indexed for MEDLINE]
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