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Trends Cell Biol. 2001 Feb;11(2):60-5.

The Pif1p subfamily of helicases: region-specific DNA helicases?

Author information

1
Dept of Molecular Biology, Princeton University, Princeton, NJ 08544, USA.

Abstract

DNA helicases are required for DNA replication, recombination and repair. Despite a common enzymatic function - the ability to unwind duplex DNA - most helicases share only limited amino acid sequence similarity. Helicases that have significant sequence similarity define a subfamily. It remains unclear, however, how this sequence similarity relates to helicase function. The Saccharomyces cerevisiae Pif1p helicase is the prototype member of a helicase subfamily that is conserved from yeasts to humans. As the two Pif1p subfamily members studied to date affect the same DNA sequences, the amino acid similarity that defines this subfamily might reflect common substrates.

PMID:
11166213
[Indexed for MEDLINE]

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