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Trends Biochem Sci. 2001 Jan;26(1):54-61.

Use of mass spectrometry-derived data to annotate nucleotide and protein sequence databases.

Author information

1
Protein Interaction Laboratory (PIL), Center for Experimental Bioinformatics, University of Southern Denmark, Campusvej 55, DK-5230, and MDS-Protana, Staermosegaardsvej 6, DK-5230, Odense M, Denmark. mann@bmb.sdu.dk

Abstract

Mass spectrometry-based proteomic methodologies can be used to annotate both nucleotide and protein sequence databases. Because such data have to be derived from proteins, they can be used to identify coding regions of the genome as well as provide the complete primary sequence of proteins and their expression patterns and post-translational modifications.

PMID:
11165518
DOI:
10.1016/s0968-0004(00)01726-6
[Indexed for MEDLINE]

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