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Trends Biochem Sci. 2001 Jan;26(1):36-40.

The alpha and the beta: protein translocation across mitochondrial and plastid outer membranes.

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Russell Grimwade School of Biochemistry and Molecular Biology, University of Melbourne, Parkville, 3010, Australia.


In the evolution of mitochondria and plastids from endosymbiotic bacteria, most of the proteins that make up these organelles have become encoded by nuclear genes and must therefore be transported across the organellar membranes, following synthesis in the cytosol. The core component of the protein translocation machines in both the mitochondrial and plastid outer membranes appears to be a beta-barrel protein, perhaps a relic from their bacterial ancestry, distinguishing these translocases from the alpha-helical-based protein translocation pores found in all other eukaryotic membranes.

[Indexed for MEDLINE]

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