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Trends Biochem Sci. 2001 Jan;26(1):3-6.

Type I secretion and multidrug efflux: transport through the TolC channel-tunnel.

Author information

1
Department of Crystallography, Birkbeck College, Malet Street, WC1E 7HX, London, UK. s.buchanan@mail.cryst.bbk.ac.uk

Abstract

The crystal structure of TolC from Escherichia coli was recently determined to 2.1-A resolution and shows a unique type of channel architecture: a 12-stranded beta-barrel spans the outer membrane and is attached to a long alpha-helical channel that penetrates far into the periplasm. The structure suggests a mechanism for its role in secretion of proteins and in efflux of toxic small molecules. The TolC export pathway is compared with several import pathways of gram-negative bacteria where the outer membrane protein structures are also known.

PMID:
11165499
DOI:
10.1016/s0968-0004(00)01733-3
[Indexed for MEDLINE]

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