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FEBS Lett. 2001 Feb 2;489(2-3):259-62.

Mutation in the NDUFS4 gene of complex I abolishes cAMP-dependent activation of the complex in a child with fatal neurological syndrome.

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1
Department of Medical Biochemistry and Biology, University of Bari, Italy. papabchm@cimedoc.uniba.it

Abstract

Evidence is presented showing that in a patient with fatal neurological syndrome, the homozygous 5 bp duplication in the cDNA of the NDUFS4 18 kDa subunit of complex I abolishes cAMP-dependent phosphorylation of this protein and activation of the complex. These findings show for the first time that human complex I is regulated via phosphorylation of the subunit encoded by the NDUFS4 gene.

PMID:
11165261
[Indexed for MEDLINE]
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