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Antiviral Res. 2000 Dec;48(3):205-8.

Parapoxviruses are strongly inhibited in vitro by cidofovir.

Author information

1
Moredun Research Institute, Pentlands Science Park, Bush Loan, EH26 0PZ, Edinburgh, UK. nettp@mri.sari.ac.uk

Abstract

Three parapoxviruses which cause orf or related diseases in humans and animals and the orthopoxvirus, vaccinia virus, were tested for their in vitro sensitivity to cidofovir. The 50% inhibitory concentration for the three parapoxviruses was between 0.21 and 0.27 microg/ml and for vaccinia was 1.32 microg/ml. The selectivity index varied from 198 to 264 for the parapoxviruses and was 42 for vaccinia virus. Virus yield assays confirmed the ability of cidofovir to reduce ortho- and parapoxvirus replication. The efficacy of cidofovir against parapoxviruses justifies its evaluation as a candidate drug for the treatment of parapoxvirus infections in humans and animals.

PMID:
11164507
DOI:
10.1016/s0166-3542(00)00130-3
[Indexed for MEDLINE]

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