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FEBS Lett. 2001 Jan 19;488(3):206-10.

Aspirin promotes TFF2 gene activation in human gastric cancer cell lines.

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Division of Molecular Genetics, Institute of Anthropology and Human Genetics, University of Tübingen, Wilhelmstr. 27, D-72074, Tübingen, Germany.


Trefoil factor family (TFF) peptides promote cell migration, heal the mucosa and may suppress tumor growth. In reporter gene assays we show that aspirin (1-12 mM) evokes a six-fold up-regulation of TFF2, but not TFF1 and TFF3 transcription in human gastrointestinal cell lines. 6 h after application up-regulation of endogenous TFF2 mRNA was observed. TFF2 transcription was enhanced by indomethacin and arachidonic acid but repressed by staurosporine, suggesting mediation via protein kinase C. We mapped an aspirin responding element -546 to -758 bp upstream of TFF2. Up-regulation of TFF2 by aspirin may partially explain the chemopreventive potential of low dose aspirin in gastrointestinal carcinogenesis.

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