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Curr Opin Genet Dev. 2001 Feb;11(1):54-9.

Know thy neighbor: stromal cells can contribute oncogenic signals.

Author information

1
Department of Pathology and UCSF Comprehensive Cancer Center, University of California at San Francisco, San Francisco, California 94143-0506, USA. tlsty@itsa.ucsf.edu
2
U CA, San Francisco

Abstract

Although the stroma within carcinogenic lesions is known to be supportive and responsive to tumors, new data increasingly show that the stroma also has a more active, oncogenic role in tumorigenesis. Stromal cells and their products can transform adjacent tissues in the absence of pre-existing tumor cells by inciting phenotypic and genomic changes in the epithelial cells. The oncogenic action of distinctive stromal components has been demonstrated through a variety of approaches, which provide clues about the cellular pathways involved.

PMID:
11163151
[Indexed for MEDLINE]
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