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Curr Opin Cell Biol. 2001 Feb;13(1):68-75.

Asymmetric cell division: fly neuroblast meets worm zygote.

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Institute of Molecular Biology, Institute of Neuroscience, Howard Hughes Medical Institute, 1254 University of Oregon, Eugene, Oregon 97403, USA.


Both Drosophila neuroblasts and Caenorhabditis elegans zygotes use a conserved protein complex to establish cell polarity and regulate spindle orientation. Mammalian epithelia also use this complex to regulate apical/basal polarity. Recent results have allowed us to compare the mechanisms regulating asymmetric cell division in Drosophila neuroblasts and the C. elegans zygote.

[Indexed for MEDLINE]

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