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Curr Opin Cell Biol. 2001 Feb;13(1):61-7.

Ankyrins and cellular targeting of diverse membrane proteins to physiological sites.

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Howard Hughes Medical Institute and the Departments of Cell Biology and Biochemistry, Duke University Medical Center, Durham, North Carolina 27710, USA.


Ankyrins are spectrin-binding proteins that associate via ANK repeats with a variety of ion channels/pumps, calcium release channels and cell adhesion molecules. Recent studies in mice indicate that ankyrins have a physiological role in restricting voltage-gated sodium channels and members of the L1 CAM family of cell adhesion molecules to excitable membranes in the central nervous system and in targeting calcium-release channels to the calcium homeostasis compartment of striated muscle.

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