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Curr Opin Cell Biol. 2001 Feb;13(1):55-60.

The FtsZ protofilament and attachment of ZipA--structural constraints on the FtsZ power stroke.

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Department of Cell Biology, Box 3709, Research Drive, Duke University Medical Center, Durham, North Carolina 27710, USA.


Bacterial cell division protein FtsZ forms protofilaments in vitro that can shift from a straight to a curved conformation. The inside of the curved protofilaments, which corresponds to the carboxyl terminus, should face the center of the cell as curvature increases during constriction of the Z-ring. ZipA, a membrane-tethered division protein, binds to a highly conserved short peptide on the carboxyl terminus of FtsZ. A model is proposed here for how membrane-bound ZipA can reach around the FtsZ protofilament to bind the carboxy-terminal peptide, which faces away from the membrane.

[Indexed for MEDLINE]

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