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Curr Opin Cell Biol. 2001 Feb;13(1):36-40.

The UNC-104/KIF1 family of kinesins.

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  • 1University of Virginia, Department of Biology, Gilmer Hall, Room 229, Charlottesville, Virginia 22903, USA.


Most UNC-104/KIF1 kinesins are monomeric motors that transport membrane-bounded organelles toward the plus ends of microtubules. Recent evidence implies that KIF1A, a synaptic vesicle motor, moves processively. This surprising behavior for a monomeric motor depends upon a lysine-rich loop in KIF1A that binds to the negatively charged carboxyl terminus of tubulin and, in the context of motor processivity, compensates for the lack of a second motor domain on the KIF1A holoenzyme.

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