Send to

Choose Destination
Cancer Lett. 2001 Feb 10;163(1):1-5.

Poly(APD-ribosyl)ation, a DNA damage-driven protein modification and regulator of genomic instability.

Author information

Department of Gerontology, Institute for the Health of the Elderly, University of Newcastle upon Tyne, IHE, Wolfson Research Centre, Newcastle General Hospital, Westgate Road, NE4 6BE, UK.


Activation of poly(ADP-ribose) polymerase-1 (PARP-1) is an immediate cellular reaction to DNA strand breakage as induced by alkylating agents, ionizing radiation or oxidants. The resulting formation of protein-coupled poly(ADP-ribose) facilitates survival of proliferating cells under conditions of DNA damage, probably via its contribution to DNA base-excision repair. Furthermore, based on recent results there is a role emerging for PARP-1 as a negative regulator of genomic instability in cells under genotoxic stress. Regarding possible applications for clinical cancer therapy with DNA-damaging agents, it appears that both inhibition and up-regulation of the poly(ADP-ribosyl)ation response in the malignant cells to be eradicated are promising strategies to improve the outcome of such therapy, albeit for different reasons.

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center