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Biochem Biophys Res Commun. 2000 Dec 29;279(3):832-7.

A new subfamily of high molecular mass CDC2-related kinases with PITAI/VRE motifs.

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Laboratoire Arago, CNRS-UMR 7628/Université Paris VI, BP 44, Banyuls-sur-Mer Cedex, F-66651, France.


Kinases of the CDC2 family play a key role in cell cycle regulation and gene expression. In the present work, we identified sea urchin and human cDNAs encoding homologues of a high molecular mass CDC2-like kinase (designated CDC2L5) sharing respectively a PITAVRE and PITAIRE motif. The human cDNA encodes the full-length amino acid sequence of the cholinesterase-related cell division controller (CHED) kinase, a previously published partial coding sequence. CDC2L5 overexpressed in mammalian cells is an approximately 170-kDa nuclear protein. The mRNA is present during the sea urchin early embryogenesis and is ubiquitously expressed in human tissues.

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