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Dev Biol. 2001 Feb 15;230(2):101-9.

Every sperm is sacred: fertilization in Caenorhabditis elegans.

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1
Waksman Institute and Department of Genetics, Rutgers University, Piscataway, New Jersey, 08854, USA. singson@waksman.rutgers.edu

Abstract

The nematode Caenorhabditis elegans is an attractive model system for the study of fertilization. C. elegans exists as a self-fertilizing hermaphrodite or as a male. This unusual situation provides an excellent opportunity to identify and maintain sterile mutants that affect sperm and no other cells. Analysis of these mutants can identify genes that encode proteins required for gamete recognition, adhesion, signaling, fusion, and/or activation at fertilization. These genes can also provide a starting point for the identification of additional molecules required for fertility. This review describes progress in the genetic and molecular dissection of fertilization in C. elegans and related studies on sperm competition.

PMID:
11161565
DOI:
10.1006/dbio.2000.0118
[Indexed for MEDLINE]
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