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Br J Cancer. 2001 Feb 2;84(3):397-9.

Risk of breast cancer among Norwegian women with visual impairment.

Author information

1
The Cancer Registry of Norway, Montebello N-0310, Oslo, Norway.

Abstract

Experimental studies suggest that melatonin has a protective effect against breast cancer. Exposure to light suppresses melatonin secretion, but to a lesser degree in totally blind persons. Breast cancer was investigated in a cohort of 15 412 Norwegian visually impaired women. The risk among totally blind women was 0.64 (95% CI = 0.21-1.49, 5 cases only), and for those who became blind before age of 65, the SIR was 0.51 (95% CI = 0.11-1.49). Our findings give support to the 'melatonin hypothesis'.

PMID:
11161406
PMCID:
PMC2363754
DOI:
10.1054/bjoc.2000.1617
[Indexed for MEDLINE]
Free PMC Article

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