Abstract
Vibrio cholerae synthesizes the catechol siderophore vibriobactin. In this report, we present the complete map of a vibriobactin gene region containing two previously unreported vibriobactin biosynthetic genes. vibD encodes a phosphopantetheinyl transferase, and vibH encodes a novel nonribosomal peptide synthase. Both VibD and VibH are required for vibriobactin biosynthesis.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Bacterial Proteins / genetics
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Bacterial Proteins / metabolism
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Catechols / chemistry
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Catechols / metabolism*
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Enterobactin / metabolism
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Genes, Bacterial
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Molecular Sequence Data
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Multigene Family
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Oxazoles*
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Peptide Synthases / genetics*
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Peptide Synthases / metabolism
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Plasmids
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Transferases (Other Substituted Phosphate Groups) / genetics*
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Transferases (Other Substituted Phosphate Groups) / metabolism
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Vibrio cholerae / enzymology*
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Vibrio cholerae / genetics
Substances
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Bacterial Proteins
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Catechols
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Oxazoles
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Enterobactin
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vibriobactin
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Transferases (Other Substituted Phosphate Groups)
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holo-(acyl-carrier-protein) synthase
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Peptide Synthases