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Science. 2001 Feb 2;291(5505):872-5. Epub 2001 Jan 18.

Lack of replicative senescence in normal rodent glia.

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1
MRC Laboratory for Molecular Cell Biology, University College London, Gower Street, London WC1E 6BT, UK.

Abstract

Replicative senescence is thought to be an intrinsic mechanism for limiting the proliferative life-span of normal somatic cells. We show here that rat Schwann cells can be expanded indefinitely in culture while maintaining checkpoints normally lost during the immortalization process. These findings demonstrate that senescence is not an inevitable consequence of extended proliferation in culture.

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PMID:
11157166
DOI:
10.1126/science.1056782
[Indexed for MEDLINE]
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