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Curr Opin Immunol. 2001 Feb;13(1):32-6.

The control and facilitation of MHC class II antigen processing by the BCR.

Author information

1
Department of Medicine, Section of Rheumatology, University of Chicago, 5841 South Maryland Avenue, MCV0930, Chicago, IL 60637, USA. ksiemask@midway.uchicago.edu

Abstract

Antigens capable of cross-linking the BCR are preferentially captured, processed and presented to MHC-class-II-restricted T cells. Cross-linking antigens initiate tyrosine-kinase-dependent pathways that accelerate the delivery of antigen-receptor complexes to specialized late-endocytic processing compartments. Accelerated trafficking is mediated by the recruitment of signaling molecules required for transience through specific checkpoints along the endocytic pathway.

PMID:
11154914
[Indexed for MEDLINE]
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