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Curr Opin Immunol. 2001 Feb;13(1):26-31.

Antigen processing in the endocytic compartment.

Author information

1
Wellcome Trust Biocentre, University of Dundee, Dow Street, Dundee DD1 5EH, UK. c.watts@dundee.ac.uk

Abstract

Proteolysis generates the peptides that bind to class II MHC molecules and, by destruction of the invariant chain, prepares the class II MHC molecule for capture of those peptides. A clearer picture is emerging of the proteases, protease inhibitors and other factors that together control the environment for class II MHC peptide loading. However, the details of invariant-chain processing and antigen processing may differ depending on the allele of class II and the antigen substrate under consideration.

PMID:
11154913
[Indexed for MEDLINE]

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