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J Pediatr Endocrinol Metab. 2000 Nov-Dec;13(9):1571-6.

Cord blood and postnatal serum leptin and its relationship to steroid use and growth in sick preterm infants.

Author information

1
Department of Pediatrics, Washington University School of Medicine, St. Louis, MO 63110, USA. Shekhawat_P@kids.wustl.edu

Abstract

OBJECTIVE:

To study the effect of prenatal and postnatal glucocorticoids use on serum leptin and weight gain in sick preterm infants and its correlation with caloric intake.

METHODS:

Serum leptin was measured in 24 neonates at day 1 (cord), 14 and 28 by radioimmunoassay. Total caloric intake (enteral and parenteral) and weight were measured on days 14 and 28 of life.

RESULTS:

Mean birth weight and gestational age of study infants were 864 +/- 273 g (mean +/- SD) (range 520-1755 g), and 26.6 +/- 2.4 weeks (23-32 weeks) respectively. Cord blood leptin was greater in infants whose mothers received antenatal steroids (1.98 +/- 1.05 ng/ml vs 0.94 +/- 0.39 ng/ml, p=0.004). Serum leptin increased postnatally from 1.52 +/- 1.0 ng/ml at birth to 2.2 +/- 1.3 ng/ml on day 28 of life (p=0.03). Mean serum leptin had an inverse exponential relationship with postnatal weight gain by day 28 of life (R2=0.56). Total caloric intake on days 14 and 28 of life did not correlate with postnatal weight gain.

CONCLUSIONS:

Increased serum concentration of leptin following glucocorticoids may be associated with poor weight gain in sick preterm infants.

PMID:
11154152
[Indexed for MEDLINE]
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