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FEBS Lett. 2000 Dec 22;487(1):95-100.

Genomic exploration of the hemiascomycetous yeasts: 17. Yarrowia lipolytica.

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Collection de Levures d'Intérêt Biotechnologie, Laboratoire de Génétique Moléculaire et Cellulaire, INA-PG, INRA, UMR216, CNRS URA1925, Thiverval-Grignon, France.


A total of 4940 random sequence tags of the dimorphic yeast Yarrowia lipolytica, totalling 4.9 Mb, were analyzed. BLASTX comparisons revealed at least 1229 novel Y. lipolytica genes 1083 genes having homology with Saccharomyces cerevisiae genes and 146 with genes from various other genomes. This confirms the rapid sequence evolution assumed for Y. lipolytica. Functional analysis of newly discovered genes revealed that several enzymatic activities were increased compared to S. cerevisiae, in particular, transport activities, ion homeostasis, and various metabolism pathways. Most of the mitochondrial genes were identified in contigs spanning more than 47 kb. Matches to retrotransposons were observed, including a S. cerevisiae Ty3 and a LINE element. The sequences have been deposited with EMBL under the accession numbers AL409956-AL414895.

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