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Am J Cardiol. 2001 Jan 15;87(2):232-4, A9.

Effectiveness of high doses of simvastatin as monotherapy in mixed hyperlipidemia.

Author information

1
Division of Cardiology, University of Maryland Medical Center, Baltimore, USA. mmiller@heart.umaryland.edu

Abstract

Twenty subjects with mixed hyperlipidemia participated in a 3-arm crossover trial to evaluate the effectiveness of high-dose simvastatin as monotherapy. Significant reductions were observed in atherogenic lipids and lipoproteins. The highest dose of simvastatin also resulted in significant increases in high-density lipoprotein cholesterol (21%) with a comparable increase in large, protective high-density lipoprotein particles.

PMID:
11152850
DOI:
10.1016/s0002-9149(00)01327-8
[Indexed for MEDLINE]

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